Do any macro's at all work on the Win10 box your having issues with? Are you running your macro's in a clean desktop? I mean, are you testing some simple macro's with nothing else open on the Win10 box? Are you running the macro within a virtual machine or against any virtualization? (within a VMWare host, Hyper-V, Remote Desktop session, etc) Are you running the macro in a game, be it a full screen game or not? Are you running the macro within a web browser, application, something with Java/flash? Why do you think it works on your others Windows 10 boxes but not this one? Do you have any guesses why? Is there something different between this box and your other boxes?